What makes managing employee health and safety programs around the work so difficult?

What makes managing employee health and safety programs around the work so difficult?
2. Why is designing and implementing a global human resource information system so difficult? What kinds of problems need to be overcome?
3. What are the major differences between macro- and micro-regions?
4. In many regions and countries governments face pressures to increase the age when a person can retire. What are the major implications for raising the retirement age from:
a. a MNE’s perspective? and
b. the HRM manager’s perspective?